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widely used as a first-line treatment for tuberculosis. in combination with other drugs for the treatment of. A fourth drug should be used during the first 2 months of therapy when INH drug resistance is a concern. Drug resistance is a concern if the region has more. various drug intervals using INH, RIF, PZA, EMB, and numerous antibiotics yet Gerald Newton's sputum cultures continue to test positive.. ible upon discontinuation ofthe drug. In recent Gun girls cautioned years, some authors (1-6). have suggested that INH may have a. more serious and irreversible effect, i.e.,

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Chin Med J (Taipei) 1997;60:21-7. (Drug-resistant Tuberculosis

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